Dr. Jesús Valdés Flores

Dr. Valdés

 

Investigador Titular (Cinvestav 3-C)
Doctor en Ciencias (Biología Molecular 1990) CINVESTAV.


Temas de investigación:

Metabolismo de pre-mRNAs. Splicing alternativo de transcritos marcadores de cáncer y supresores de tumores. Splicing de Entamoeba sp. Unión de proteínas y RNA: función en el splicing. Estructuras de orden superior del RNA y su relación con el splicing.


Membresía del SNI:  Nivel II
Teléfono:  (52) (55) 5747-3954
Correo-e: jvaldes@yupisnoopycinvestav.mx

 

 

 

Julio César Torres-Romero, José Luis Villalpando, Julio Lara-Riegos, Jesús Valdés, Elisa Azuara-Liceaga, Antonio Euan-Canto, César López-Camarillo, María Elizbeth Alvarez-Sánchez. In silico analysis of putative metal response elements (MREs) in the zinc-responsive genes from Trichomonas vaginalis and the identification of novel palindromic MRE-like motif. BioMetals. 2020 Oct; 33(4-5):229-240.
doi: 10.1007/s10534-020-00246-0
Descarga PDF Texto completo...

José Manuel Jáuregui-Wade, Jorge Cerbón-Solórzano, Ricardo Avila-García, Jorge Tonatiuh Ayala-Sumuano, Jesús Valdés. Ceramide synthase 2 knockdown suppresses trophozoite growth, migration, in vitro encystment and excystment of Entamoeba invadensBiochem Biophys Res Commun. 2020 Mar 26; 524(1):135-141.
doi: 10.1016/j.bbrc.2020.01.093
Descarga PDF Texto completo...

Ricardo Avila-García, Jesús Valdés, José Manuel Jáuregui-Wade, Jorge Tonatiuh Ayala-Sumuano, Jorge Cerbón-Solórzano. The metabolic pathway of sphingolipids biosynthesis and signaling in Entamoeba histolytica. Biochem Biophys Res Commun. 2020 Feb 12; 522(3):574-579.
doi: 10.1016/j.bbrc.2019.11.116
Descarga PDF Texto completo...

Ana B. Villaseñor-Altamirano, John D. Watson, Stephenie D. Prokopec, Cindy Q. Yap, Paul C. Boutros, Raimo Pohjanvirta, Jesús Valdés-Flores, Guillermo Elizondo. 2,3,7,8-Tetrachlorodibenzo-p-dioxin modifies alternative splicing in mouse liver. Plos One. 2019; 14(8): e0219747.
doi: 10.1371/journal.pone.0219747
Descarga PDF Texto completo...

Sheila A Villa-Cedillo, Adolfo Soto-Domínguez, Humberto Rodríguez-Rocha, Aracely García-García, María de Jesús Loera-Arias, Luis F Rivera-Chávez, Esrom J Acosta-Espinoza, Jesús Valdés, Laura M Zavala-Flores, Roberto Montes-de-Oca-Luna and Odila Saucedo-Cárdenas. The mRVG-9R peptide as a potential therapeutic vector to the central nervous system cells. Cell Biology International. (2019) 43: 809-819.
doi: 10.1002/cbin.11161
Descarga PDF Texto completo...

Karen Cortés-Sarabia, Yolanda Medina-Flores, Luz Del Carmen Alarcón-Romero, Olga Mata-Ruíz, Amalia Vences-Velázquez, Hugo Alberto Rodríguez-Ruíz, Jesús Valdés and Carlos Ortuño-Pineda. Production and characterization of monoclonal antibodies against the DNA binding domain of the RE1-silencing transcription factor.  J. Biochem. 2019;0(0):1–10.
doi: 10.1093/jb/mvz046
Descarga PDF Texto completo...

Aida Castillo, Carlos Ortuño-Pineda, Catalina Flores-Maldonado, Isabel Larre, Jacqueline Martínez Rendón, Lorena Hinojosa, Arturo Ponce, Alejandro Ogazón, Mauricio Serrano, Jesús Valdés, Rubén G. Contreras, Marcelino Cereijido. Ouabain Modulates the Adherens Junction in Renal Epithelial Cells. Cell Physiol Biochem. 2019;52:1381-1397.
doi: 10.33594/000000097
Descarga PDF Texto completo...

José Manuel Jáuregui-Wade, Jesús Valdés, Jorge Tonatiuh Ayala-Samuano, Ricardo Ávila-García, Jorge Cerbón-Solorzano. De novo synthesis of sphingolipids plays an important role during in vitro encystment of Entamoeba invadens. Biochem. Biophys. Res. Commun. 2019 Jan 22; 508(4):1031-1037.
doi: 10.1016/j.bbrc.2018.12.005
Descarga PDF Texto completo...

M De Nova-Ocampo, MC Soliman, W Espinosa-Hernández, C Velez-del Valle, J Salas-Benito, J Valdés-Flores, L García-Morales. Human astroviruses: in silico analysis of the untranslated region and putative binding sites of cellular proteins. Review. Molecular Biology Reports. 2018.
doi: 10.1007/s11033-018-4498-8
Descarga PDF Texto completo...

FJ Rendón-Gandarilla, V Álvarez-Hernández, EJ Castañeda-Ortiz, H Cárdenas-Hernández, RE Cárdenas-Guerra, J Valdés, A Betanzos, B Chávez-Munguiía, A Lagunes-Guillen, E Orozco, L López-Canovas, E Azuara-Liceaga. Telomeric Repeat-Binding Factor Homologs in Entamoeba histolytica: New Clues for Telomeric Research. Front Cell Infect Microbiol, October 2018.
doi: 10.3389/fcimb.2018.00341
Descarga PDF Texto completo...

MS Mendoza-Figueroa, EE Alfonso-Maqueira, C Vélez, EI Azuara-Liceaga, S Zárate, N Villegas-Sepúlveda, O Saucedo-Cárdenas, J Valdés. Post Splicing-Derived Full-Length Intron Circles in the Protozoan Parasite Entamoeba histolytica. Front Cell Infect Microbiol, July 2018.
doi: 10.3389/fcimb.2018.00255
Descarga PDF Texto completo...

DM Torres-Cifuentes, JM Galindo-Rosales, O Saucedo-Cárdenas, J Valdés. The Entamoeba histolytica Syf1 Homolog Is Involved in the Splicing of AG-Dependent and AG-Independent Transcripts. Front Cell Infect Microbiol, 09 July 2018.
doi: 10.3389/fcimb.2018.00229
Descarga PDF Texto completo...

J Valdés, C Ortuño-Pineda, O Saucedo-Cárdenas, MS Mendoza-Figueroa. Unexplored Molecular Features of the Entamoeba histolytica RNA Lariat Debranching Enzyme Dbr1 Expression Profile. Front Cell Infect Microbiol, 04 July 2018.
doi: 10.3389/fcimb.2018.00228
Descarga PDF Texto completo...

J Valdés-Flores, I López-Rosas, C López-Camarillo, E Ramírez-Moreno, JD Ospina-Villa, LA Marchat. Life and Death of mRNA Molecules in Entamoeba histolytica. Front Cell Infect Microbiol, 19 June 2018.
doi: 10.3389/fcimb.2018.00199
Descarga PDF Texto completo...

RK Narayanasamy, CA Castañón-Sánchez, JP Luna-Arias, G García-Rivera, B Avendaño-Borromeo, ML Labra-Barrios, J Valdés, ME Herrera-Aguirre, E Orozco. The Entamoeba histolytica TBP and TRF1 transcription factors are GAAC-box binding proteins, which display differential gene expression under different stress stimuli and during interaction with mammalian cells. Parasites and Vectors. 11 (1):153. 2018
doi: 10.1186/s13071-018-2698-7
Descarga PDF Texto completo...

J Valdés, G. Kutralam-Muniasamy, B. Vergara-Porras, R. Marsch, F. Pérez-Guevara, M.R. López-Cuellar. Heterologous expression of phaC2 gene and poly-3-hydroxyalkanoate production by recombinant Cupriavidus necator strains using canola oil as carbon source. New Biotechnology. 40: 200-206. 2018.
doi: 10.1016/j.nbt.2017.08.001
Descarga PDF Texto completo...

José Luis Villalpando, Rodrigo Arreola, Jonathan Puente-Rivera, Elisa Azuara-Liceaga, Jesús Valdés, Lilia López-Canovas, Alma Villalobos-Osnaya, Maria Elizbeth Alvarez-Sánchez. TvZNF1 is a C2H2 zinc finger protein of Trichomonas vaginalis. Biometals. 30, Issue 6: 861-87. 2017.
doi: 10.1007/s10534-017-0053-7
Descarga PDF Texto completo...

Daniel Leon-Aparicio, Jonathan Pacheco, Jesus Chavez-Reyes, Jose M. Galindo, Jesus Valdes, Luis Vaca, Agustin Guerrero-Hernandez. Orai3 channel is the 2-APB-induced endoplasmic reticulum calcium leak. Cell Calcium.  2017 Jul; 65:91-101.
doi: 10.1016/j.ceca.2017.01.012
Descarga PDF Texto completo...

Daniela Lozano-Amado, Abril Marcela Herrera-Solorio, Jesús Valdés, Leticia Alemán-Lazarini, Ma. de Jesús Almaraz-Barrera, Eva Luna-Rivera, Miguel Vargas and Rosaura Hernández-Rivas. Identification of repressive and active epigenetic marks and nuclear bodies in Entamoeba histolytica. Parasites & Vectors 9:19. 2016.
doi: 10.1186/s13071-016-1298-7
Descarga PDF Texto completo...

J. Gustavo Vázquez-Jiménez, Jesús Chávez-Reyes, Tatiana Romero-García, Ángel Zarain-Herzberg, Jesús Valdés-Flores, J. Manuel Galindo-Rosales, Angélica Rueda, Agustín Guerrero-Hernández, J. Alberto Olivares-Reyes. Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. Cellular Signalling. 28 (2016): 53-59;
doi: 10.1016/j.cellsig.2015.10.001
Descarga PDF Texto completo...

Pedro A. Mendoza Pablo, Jesús Valdés, Luis Ortiz-Hernández. Accuracy of body mass index for age to diagnose obesity in Mexican schoolchildren. Nutr Hosp 31(6):2668-2675. 2015;
doi: 10.3305/nh.2015.31.6.8639
Descarga PDF Texto completo...

Valdés, J., Nozaki, T., Sato, E., Chiba, Y., Nakada-Tsukui, K., Villegas-Sepúlveda, N., Winkler, R., Azuara-Liceaga, E., Mendoza-Figueroa, M.S., Watanabe, N., Santos, H.J., Saito-Nakano, Y., Galindo-Rosales, J.M. Proteomic analysis of Entamoeba histolytica in vivo assembled pre-mRNA splicing complexes. J Proteomics. (2014); 111: 30-45.
doi: 10.1016/j.jprot.2014.07.027
Descarga PDF Texto completo...

Martínez-Salazar, M., López-Urrutia, E., Arechaga-Ocampo, E., Bonilla-Moreno, R., Martínez-Castillo, M., Díaz-Hernández, J., Del Moral-Hernández, O., Cedillo-Barrón, L., Martines-Juarez, V., De Nova-Ocampo, M., Valdés, J., Berumen, J., Villegas-Sepúlveda, N. Biochemical and proteomic analysis of spliceosome factors interacting with intron-1 of human papillomavirus type-16. J Proteomics. (2014) 111: 184-97.
doi: 10.1016/j.jprot.2014.07.029
Descarga PDF Texto completo...

Wendy Espinosa-Hernández, Dora Velez-Uriza, Jesús Valdés, Cristina Vélez-Del Valle, Juan Salas-Benito, Rebeca Martínez-Contreras, Matilde García-Espítia, Mariana Salas-Benito, Tania Vega-Almeida, Mónica De Nova-Ocampo. PTB Binds to the 3' Untranslated Region of the Human Astrovirus Type 8: A Possible Role in Viral Replication. Plos One. (2014), 9 (11): 1-10;
doi: 10.1371/journal.pone.0113113
Descarga PDF Texto completo...

Ortiz-Melo, M.T., Sánchez-Guzmán, E., González-Robles, A., Valdés, J., Gómez-Flores, E., Castro-Muñozledo, F. Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier. Biol Open. (2013) 2(2):132-143.
doi: 10.1242/bio.20123145
Descarga PDF Texto completo...

Pérez Salgado, D., Valdés-Flores, J., Janssen, I., Ortiz-Hernández, L. Diagnosis and treatment of obesity among Mexican adults. Obes Facts. (2012) 5(6):937-946.
Descarga PDF Texto completo...

Aguilar-Rojas, A., Huerta-Reyes, M., Maya-Núñez, G., Arechavaleta-Velásco, F., Conn, P.M., Ulloa-Aguirre, A. and Valdés, J. Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231. BMC Cancer. (2012) 12:550.
doi: 10.1186/1471-2407-12-550
Descarga PDF Texto completo...

Ortuño-Pineda, C., Galindo-Rosales, J.M., Calderón-Salinas, J.V., Villegas-Sepúlveda, N., Saucedo-Cárdenas, O., De Nova-Ocampo, M., Valdés, J. Binding of hnRNP H and U2AF65 to respective G-codes and a poly-uridine tract collaborate in the N50-5'ss selection of the REST N exon in H69 cells. PLoS One. (2012) 7(7):e40315.
Descarga PDF Texto completo...

López-Urrutia, E., Valdés, J., Bonilla-Moreno, R., Martínez-Salazar, M., Berumen, J. and Villegas-Sepúlveda, N. A few nucleotide polymorphisms are sufficient to recruit nuclear factosr differentially to the intron 1 of HPV-16 intratypic variants. Virus Res. (2012) 166(1-2):43-53.
Descarga PDF Texto completo...

Reyes-Escogido, L., Balam-Chi, M., Rodríguez-Buenfil, I., Valdés, J., Kameyama, L., and Martínez-Pérez, F. Purification of bacterial genomic DNA in less than 20 min using chelex-100 microwave: examples from strains of lactic acid bacteria isolated from soil samples. Antonie Van Leeuwenhoek. (2010) 98(4):465-474.
Descarga PDF Texto completo...

Navarro-Moreno, L.G., Quintanar-Escorza, M.A., González, S., Mondragón, R., Cerbón-Solorzáno, J.,Valdés, J. and Calderón-Salinas, J.V. Effects of lead intoxication on intercellular junctions and biochemical alterations of the renal proximal tubule cells. Toxicology in Vitro. (2009) 23(7):1298-1304.
Descarga PDF Texto completo...

Ortiz-Hernández, L., Gómez-Tello, B.L. and Valdés, J. The association of sexual orientation with self-rated health, and cigarette and alcohol use in Mexican adolescents and youths. Social Science & Medicine. (2009) 69(1):85-93.
Descarga PDF Texto completo...

Zavala-Flores, L.M., Villatoro-Hernandez, J., Gamez-Escobedo, A., Franco-Molina, M., Rangel-Colmenero, B.R., Villanueva-Olivo, A., Gutierrez-Puente, Y., Montes de Oca-Luna, R., Valdés, J. and Saucedo-Cardenas, O. Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis. Biotechnol Lett. (2009) 31(2):215-220.
Descarga PDF Texto completo...

Ortiz-Hernández, L., López-Olmedo, N.P., Genis-Gómez, M.T., Melchor-López, D.P. and Valdés-Flores, J. Application of Body Mass Index to schoolchildren of Mexico City. Ann Nutr Metab (2008) 53(3-4):205-214.
Descarga PDF Texto completo...

Villatoro-Hernandez, J., Loeara-Arias, M.J., Gamez-Escobedo, A., Franco-Molina, M., Gomez-Gutierrez, J.G., Rodriguez-Rocha, H., Gutierrez-Puente, Y., Saucedo-Cardenas, O., Valdés, J. and Montes-de-Oca-Luna, R. Secretion of biologically active intereferon-gamma inducible protein-I0 (IP-I0) by Lactococcus lactis. Microbial Cell Factories. (2008) 7:22.
Descarga PDF Texto completo...

Martínez, S., Fajardo, R., Valdés, J., Ulloa-Arvizu, R. and Rogelio, A. Histopathologic study of long-bone growth plates confirms the basset hound as an osteochondrodysplastic breed. Can J Vet Res. 2007; 71(1):66-69.
Descarga PDF Texto completo...

Martínez-Pérez, F., Zinker, S., Aguilar, G., Valdés, J. and Aréchiga, H. Circadian oscillations of RPCH gene expression in the eyestalk of the crayfish Cherax quadricarinatus. Peptides. (2005) 26(12):2434-2444.
Descarga PDF Texto completo...

Martínez-Contreras, R., Galindo, J.M., Aguilar-Rojas, A. and Valdés, J. Two exonic elements in the flanking constitutive exons control the alternative splicing of the a exon of the ZO-1 pre-mRNA. Biochim Biophys Acta. (2003) 1630(2-3):71-83.
Descarga PDF Texto completo...

Martínez-Pérez, F., Becerra, A., Valdés, J., Zinker, S.and Aréchiga, H. A possible molecular ancestor for mollusk APGWamide, insect adipokinetic hormone, and crustacean red pigment concentrating hormone. J Mol Evol (2002) 54(6):703-714.
Descarga PDF Texto completo...

Martínez-Pérez, F., Valdés, J., Zinker, S. and Aréchiga, H. The genomic organization of the open reading frame of the red pigment concentrating hormone gene in the blue crab Callinectes sapidus. Peptides. (2002) 23(4):781-786.
Descarga PDF Texto completo...

González-Mariscal, L., Islas, S., Contreras, R.G., García-Villegas, M.R., Betanzos, A., Vega, J., Díaz-Quiñones, A., Martín-Orozco, N., Ortiz-Navarrete, V., Cereijido, M. and Valdés, J. Molecular characterization of the tight junction protein ZO-1 in MDCK cells. Exp Cell Res (1999) 248(1):97-109.
Descarga PDF Texto completo...

Cereijido, M., Valdés, J., Shoshani, L. and Contreras, R.G. Role of tight junctions in stablishing and mantaining cell polarity. Annu Rev Physiol, (1998) 60:161/177.
Descarga PDF Texto completo...

Valdés, J., Taylor, M.C., Cross, M.A., Ligtenberg, M.J., Rudenko, G. and Borst, P. The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei. Nuclei Acids Research, (1996) 24(10):1809-1815.
Descarga PDF Texto completo...

Valdés, J, Hernández FC, Ocádiz R, Orozco E. Molecular karyotype of Entamoeba histolytica and Entamoeba invadens. Transactions of the Royal Society of Tropical Medicine and Hygiene, (1990) 84, 537-541.
Descarga PDF Texto completo...

 

 

 

Debido a que la proteína ZO-1 es el eslabón entre los componentes membranales de la Unión Estrecha (UE) con el citoesqueleto y a que la expresión de ZO-1 está finamente regulada durante la diferenciación celular, hacia abajo en células de cancer de mama y hacia arriba en células oculares de pacientes con glaucoma, en nuestro laboratorio estudiamos la estructura y la función del promotor del gen tjp-1 que codifica para ZO-1 y su relación con las patologías mencionadas.

En distintos tejidos ZO-1 ocurre en dos isoformas, ZO-1a+ y ZO-1a-, mismas que correlacionan con UE herméticas y laxas, respectivamente. Para comprender estos fenotipos estudiamos, por medio de ensayos de procesamiento in vivo y selección de factores de procesamiento.