Dra. Angélica Rueda y Sánchez de la Vega

Professor (Cinvestav 3-C)
Member of the National System of Investigators (SNI 1)

Research lines:

Local regulation (calcium sparks) of cardiac and vascular ryanodine receptor activity in metabolic alterations (i.e. metabolic syndrome, type 2 diabetes, hyperthyroidism). Functional role of sorcin-ryanodine receptor interaction under normal and pathological conditions. Identification of sorcin gene polymorphisms linked to hypertension in the Mexican population.

Phone:  (52) (55) 5747-3953
E-mail: arueda@yupisnoopycinvestav.mx



Some Representative Publications

Romero-García T, Landa-Galván HV, Pavón N, Mercado-Morales M, Valdivia HH, Rueda A. Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats. Cell Calcium (2020) 91: 102267.
doi: 10.1016/j.ceca.2020.102267

Navarro-García JA, Rueda A, Romero-García T, Aceves-Ripoll J, Rodríguez-Sánchez E, González-Lafuente L, Zaragoza C, Fernández-Velasco M, Kuro-O M, Ruilope LM, Ruiz-Hurtado G. Enhanced Klotho availability protects against cardiac dysfunction induced by uraemic cardiomyopathy by regulating Ca2+ handling. Br J Pharmacol. (2020) Aug 24.
doi: 10.1111/bph.15235

Ruíz-Hurtado G, Rueda A, Pereira L, Fernández-Velasco M. Editorial: Evolving Picture of Calcium Handling in Cardiac Disease. Front. Physiol (2020) 11:1013.
doi: 10.3389/fphys.2020.01013

Landa-Galván HV, Ríos-Castro E, Romero-García T, Rueda A, Olivares-Reyes JA. Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes. PLoS ONE (2020) 15(1): e0228115.
doi: 10.1371/journal.pone.0228115

Fernández-Miranda G, Romero-García T, Barrera-Lechuga TP, Mercado-Morales M, Rueda A. Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats. Front. Physiol. (2019) 10:520;
doi: 10.3389/fphys.2019.00520

Márquez MF, Totomoch-Serra A, Rueda A, Avelino-Cruz JE, and Gallegos-Cortez A. Basic and clinical insights in catecholaminergic (familial) polymorphic ventricular tachycardia. Revista de Investigación Clínica (2019) 71:217-227;
doi: 10.24875/RIC.19002939

Salazar-Enciso R, Camacho-Concha NA, Mesquita TR, Falcón D, Benitah J, Gómez AM, Rueda A. Mineralocorticoid Receptor in Calcium Handling of Vascular Smooth Muscle Cells. Calcium and Signal Transduction John N. Buchholz and Erik J. Behringer, IntechOpen. (October 24th 2018);
doi: 10.5772/intechopen.79556

Mesquita TR, Auguste G, Falcón D, Ruiz-Hurtado G, Salazar-Enciso R, Sabourin J, Lefebvre F, Viengchareun S, Kobeissy H, Lechène P, Nicolas V, Fernández-Celis A, Lauton-Santos S, Morel E, Rueda A, López-Andrés N, Gómez AM, Lombès M, Benitah JP. Specific activation of the alternative cardiac promoter of Cacna1c by the mineralocorticoid receptor. Circ Res. (2018): 122(7):e49-e61;
doi: 10.1161/CIRCRESAHA.117.312451

De Alba-Aguayo DR, Pavón N, Mercado-Morales M, Miranda-Saturnino M, López-Casamichana M, Guerrero-Hernández A, Rueda A. Increased calcium leak associated with reduced calsequestrin expression in hyperthyroid cardiomyocytes. Cell Calcium. (2017); 62:29-40;
doi: 10.1016/j.ceca.2017.01.009

Martínez-Rendón J, Sánchez-Guzmán E, Rueda A, González JE, Gulias-Cañizo R, Aquino-Jarquín G, Castro-MuñozLedo F, García-Villegas R. TRPV4 regulates tight junctions and affects differentiation in a cell culture model of the corneal epithelium. J Cell Physiol (2016) 232(7):1794-1807;
doi: 10.1002/jcp.25698

Fernández-Velasco M, Delgado C, Ruiz-Hurtado G, Gómez-Hurtado N, González-Ramos S, Rueda A, Benito G, Prieto P, Nuñez G, Bosca L. NOD1, a new player in cardiac function and calcium handling. Cardiovasc Res. (2015); 106(3):375-86;
doi: 10.1093/cvr/cvv118

Ruiz-Hurtado G, Li L, Fernández-Velasco M, Rueda A, Lefebvre F, Wang YY, Mateo P, Cassan C, Gellen G, Benitah JP, Gómez AM. Reconciling depressed calcium sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes. J Gen Physiol. (2015); 146(4):295-306.

Fernández-Velasco M, Ruiz-Hurtado G, Gómez AM, Rueda A. Calcium handling alterations and vascular dysfunction in diabetes. Cell Calcium. (2014); 56(5): 397-407;
doi: 10.1016/j.ceca.2014.08.007

Pereira L, Ruiz-Hurtado G, Rueda A, Mercadier JJ, Benitah JP, Gómez AM. Calcium signaling in diabetic cardiomyocytes. Cell Calcium. (2014); 56(5): 372-380;
doi: 10.1016/j.ceca.2014.08.004

Rueda A, de Alba-Aguayo DR, Valdivia HH. Ryanodine receptor, calcium leak and arrhythmias. Arch Cardiol Mex. (2014); 84(3):191-201.

Gayathri N, de Alba-Aguayo DR, Mondragón-Flores R, González-Pozos S, Miranda-Saturnino MJ, Sridharan M, Rueda A. Acute administration of chitosan nanoparticles increases calcium leak in rat cardiomyocytes. J Nano Res. (2014); 28: 29-38.

Guerrero-Hernández A, Ávila G, Rueda A. Ryanodine receptors as leak channels. Eur J Pharmacol. (2014); 739: 26-38.

Rueda A, Fernández-Velasco, M, Benitah JP, Gómez AM. Abnormal Calcium Spark/STOC Coupling in Cerebral Artery Smooth Muscle Cells of Obese Type 2 Diabetic Mice. PLoS ONE. (2013) 8(1): e53321;
doi: 10.1371/journal.pone.0053321

Fernández-Velasco M, Ruiz-Hurtado G, Rueda A, Neco P, Mercado-Morales M, Delgado C, Napolitano C, Priori SG, Richard S, Gómez A, Benitah JP. RyR calcium Leak Limits Cardiac Calcium Window Current Overcoming the Tonic Effect of Calmodulinin Mice. PLOS ONE (2011) 6:e20863.

Gómez AM, Rueda A, Sainte-Marie Y, Pereira L, Zissimopoulos S, Zhu X, Schaub R, Perrier E, Perrier R, Latouche C, Richard S, Picot MC, Jaisser F, Lai FA, Valdivia HH, Benitah JP. Mineralocorticoid modulation of cardiac ryanodine receptor activity as associated with downregulation of FK506-binding proteins. Circulation (2009) 119:2179-2187.

Fernández-Velasco M, Rueda A, Rizzi N, Benitah JP, Colombi B, Napolitano C, Priori SG, Richard S, Gómez AM. Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia. Circulation Research (2009) 104:201-209.

Franceschini S, Ilari A, Verzili D, Zamparelli C, Antaramian A, Rueda A, Valdivia HH, Chiancone E, Colotti G. Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor. FASEB J (2008) 22:295-306.

Rueda A, Song M, Toro L, Stefani E, Valdivia HH. Sorcin modulation of calcium sparks in rat vascular smooth muscle cells. J Physiol (2006) 576:887-901.

Rueda A, Valdivia HH. Sorcin, an emergent modulator of ryanodine receptors in smooth muscle. J Mol Cell Cardiol (2004) 37: 152.

Farrell FE, Antaramian A, Rueda A, Gómez AM, Valdivia HH. Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart. J Biol Chem (2003) 278: 34660-34666.

Rueda A, García L, Guerrero-Hernández A. Luminal calcium and the activity of sarcoplasmic reticulum calcium pumps modulate histamine-induced all-or-none calcium release in smooth muscle cells. Cellular Signalling (2002) 14: 517-27.

Rueda A, García L, Soria-Jasso LE, Arias-Montaño JA, Guerrero-Hernández A. The initial inositol 1,4,5-trisphosphate response induced by histamine is strongly amplified by calcium release from internal stores in smooth muscle. Cell Calcium (2002) 31: 161-173.