Dr. Guillermo Ávila Flores

Professor (Cinvestav 3-D)
Member of the National System of Investigators (SNI 2)


Research lines:

Ion channels and excitation-contraction coupling. Structure-function relationship of ryanodine receptors. Intracellular calcium. Cardiac and skeletal muscle disease.


Phone:  (52) (55) 5747-3952
E-mail: gavila@yupisnoopycinvestav.mx

 

 

Some Representative Publications

Gómez-Viquez N.L., Balderas-Villalobos J., Bello-Sánchez M.D., Mayorga-Luna M., Mailloux-Salinas P., García-Castañeda M., Ríos-Pérez E.B., Mártinez-Ávila M.A., Camacho-Castillo L.D.C., Bravo G., Avila G., Altamirano J., Carvajal K.  Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca2+ waves. (2021) Arch Physiol Biochem; 1-13;
doi: 10.1080/13813455.2021.1895224

Montiel-Jaen M.A., Monsalvo-Villegas A., Avila G.Modulating ALDH2 reveals a differential dependence on ROS for hypertrophy and SR Ca2+ release in aldosterone-treated cardiac myocytes. (2021) Biochem Biophys Res Commun. 536:7-13;
doi: 10.1016/j.bbrc.2020.12.049

Avila G., de la Rosa J.A., Monsalvo-Villegas A., Montiel-Jaen M.G. Ca2+ Channels Mediate Bidirectional Signaling between Sarcolemma and Sarcoplasmic Reticulum in Muscle Cells. (2020) Cells 9(1):55;
doi: 10.3390/cells9010055

Monsalvo-Villegas A, Osornio-Garduño DS, Ávila G. Long-Term Regulation of Excitation-Contraction Coupling and Oxidative Stress in Cardiac Myocytes by Pirfenidone. Front. Physiol. (2018) 9:1801;
doi: 10.3389/fphys.2018.01801

Ávila G. Disturbed Ca2+ Homeostasis in Muscle-Wasting Disorders. In: Xiao J. (eds) Muscle Atrophy. Advances in Experimental Medicine and Biology. (2018) vol 1088. Springer, Singapore;
doi: 10.1007/978-981-13-1435-3_14

García-Castañeda M, Vega AV, Rodríguez R, Montiel-Jaen MG, Cisneros B, Zarain-Herzberg A, Ávila G. Functional impact of an oculopharyngeal muscular dystrophy mutation in PABPN1. J Physiol. (2017) 595(13):4167-4187;
doi: 10.1113/JP273948

Ríos-Pérez EB, García-Castañeda M, Monsalvo-Villegas A, Ávila G. Chronic atrial ionic remodeling by aldosterone: potentiation of L-type Ca2+ channels and its arrhythmogenic significance. Pflugers Arch. (2016) 468:1823-1835;
doi: 10.1007/s00424-016-1876-8
Texto completo...

Santamaria-Herrera MA, Ríos-Pérez EB, de la Rosa JA, García-Castañeda M, Osornio-Garduño DS, Ramos-Mondragón R, Mancilla-Percino T, Ávila G. MDIMP, a novel cardiac Ca(2+) channel blocker with atrial selectivity. Eur J Pharmacol. (2016) 15;781:218-28;
doi: 10.1016/j.ejphar.2016.04.027

Ávila G, Osornio-Garduño DS, Ríos-Pérez EB, Ramos-Mondragón R. Functional and structural impact of pirfenidone on the alterations of cardiac disease and diabetes mellitus. Cell Calcium. (2014) 56(5): 428-35;
doi: 10.1016/j.ceca.2014.07.008

Guerrero-Hernández A, Ávila G, Rueda A. Ryanodine receptors as leak channels. Eur J Pharmacol. (2014) 739: 26-38;
doi: 10.1016/j.ejphar.2013.11.016

Vega AV, Ávila G, Matthews G. Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression. Scip Rep. (2013) 3: 2809;
doi: 10.1038/srep02809

Ramos-Mondragón R., Galindo CA, García-Castañeda M, Sánchez-Vargas JL, Vega AV, Gómez-Viquez NL, G. Ávila. Chronic potentiation of cardiac L-type Ca2+ channels by pirfenidone. Cardiovasc Res. (2012) 96(2):244-54;
doi: 10.1093/cvr/cvs248

Vega, A.V., Ramos-Mondragón, R., Calderón-Rivera, A., Zarain-Herzberg, A., and G. Ávila. Calcitonin gene-related peptide restores disrupted excitation-contraction coupling in myotubes expressing central core disease mutations in RyR1. J Physiol. (2011) 589:4649-4669

Ramos-Mondragón, R., Vega, A.V., and G. Ávila. Long-term modulation of Na(+) and K(+) channels by TGF-b1 in neonatal rat cardiac myocytes. Pflugers Arch. (2011) 461:235-247

Vega, A.V., and G. Ávila. CGRP, a vasodilator neuropeptide that stimulates neuromuscular transmission and EC coupling. Current Vascular Pharmacology. (2010) 8:394-403

Calderon-Rivera, A., Vega, A.V., and G. Ávila. Creatine supplementation up-regulates excitation-contraction coupling in C2C12 myotubes. Journal of receptor ligand and channel research. (2010) 3:63-71

Ramos-Mondragon, R., Galindo, C.A., and G. Ávila. Role of TGF-ß on cardiac structural and electrical remodeling. Vascular and Health and Risk Management. (2008) 4:1289-1300

Ávila, G., Aguilar, C.I. and R. Ramos-Mondragón. Sustained CGRP1 receptor stimulation modulates development of EC coupling by cAMP/PKA signaling pathway in mouse skeletal myotubes. J Physiol. (2007) 584:47-57

Ávila, G., Medina I.M., Jiménez E., Elizondo G., and C.I. Aguilar. Transforming growth factor-beta1 decreases cardiac muscle L-type Ca2+ current and charge movement by acting on the Cav1.2 mRNA. Am J Physiol Heart Circ Physiol. (2007) 292:H622-31

Mejia-Luna L., and G. Ávila. Ca2+ channel regulation by transforming growth factor-beta1 and bone morphogenetic protein-2 in developing mice myotubes. J Physiol. (2004) 559:41-54

Du G.G., Ávila, G., Sharma, P., Khanna, V.K., Dirksen, R.T., and D.H. MacLennan. Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1). J Biol Chem. (2004) 279:37566-37574

Ávila, G., Monjaraz, E., Espinosa, J.L., and G. Cota. Downregulation of voltaje-gated sodium channels by dexamethasone in clonal rat pituitary cells. Neurosc Lett. (2003) 339:21-24

Ávila, G., Lee, E.H., Perez, C.F., Allen, P.D., and R.T. Dirksen. FKBP12 Binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. (2003) 278:22600-22608

Ávila, G., O'Connell, K.M.S., Groom, L.A., and R.T. Dirksen. Ca2+ release through ryanodine receptors regulates skeletal muscle L-Type Ca2+ channel expression. J Biol Chem. (2001) 276:17732-17738

Ávila, G., O'Brien, J.J., and R.T. Dirksen. Excitation-contraction uncoupling by a human central core disease mutation in the ryanodine receptor. Proc Natl Acad Sci USA. (2001) 98:4215-4220

Ávila, G., and R.T. Dirksen. Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca2+ channel. J Gen Physiol. (2000) 115:467-479

 

 

 

 

 

 

 


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