Dr. Jesús Alberto Olivares Reyes

Professor (Cinvestav 3-C)
Member of the National System of Investigators (SNI 2)


Research lines:

  1. Cell Signaling and Hypertension: Mechanisms of Action and Regulation of Angiotensin II and their receptors (AT1 y AT2)
  2. Cell Signaling and Insulin Resistance
  3. Metabolic Syndrome and Diabetes: Molecular mechanisms of insulin action
  4. Cell Signaling and Stress: Mechanism of Action and Regulation of the corticotropin releasing factor and their receptors (CRF1R and CRF2R)

More information...


Phone:  (52) (55) 5747-3951
E-mail: jolivare@yupisnoopycinvestav.mx

 

 

Some Representative Publications

J Gustavo Vazquez-Jimenez, M Stephanie Corpus-Navarro, J Miguel Rodriguez-Chavez, Hiram J Jaramillo-Ramirez, Judith Hernandez-Aranda, Octavio Galindo-Hernandez, J Rene Machado-Contreras, Marina Trejo-Trejo, Agustin Guerrero-Hernandez, J Alberto Olivares-Reyes. The Increased Expression of Regulator of G-Protein Signaling 2 (RGS2) Inhibits Insulin-Induced Akt Phosphorylation and Is Associated with Uncontrolled Glycemia in Patients with Type 2 Diabetes. Metabolites. 2021 Feb 5;11(2):91.
doi: 10.3390/metabo11020091.

Huguet V. Landa-Galvan, Emmanuel Rios-Castro, Tatiana Romero-Garcia, Angelica Rueda, Jesus Alberto Olivares-Reyes. Metabolic Syndrome Diminishes Insulin-Induced Akt Activation and Causes a Redistribution of Akt-interacting Proteins in Cardiomyocytes. Plos One. 2020 Jan 29; 15(1):e0228115.
doi: 10.1371/journal.pone.0228115.

G. Karina Parra-Mercado, Alma M. Fuentes-Gonzalez, Judith Hernandez-Aranda, Monica Diaz-Coranguez, Frank M. Dautzenberg, Kevin J. Catt, Richard L. Hauger, J. Alberto Olivares-Reyes. CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms. Front. Endocrinol. 2019 Dec 12; 10:869;
doi: 10.3389/fendo.2019.00869.


Roura-Guiberna, A., Hernandez-Aranda, J., Ramirez-Flores, C. J., Mondragon-Flores, R., Garibay-Nieto, N., Queipo-Garcia, G., Laresgoiti-Servitje, E., Soh, J. W., Olivares-Reyes, J. A. Isomers of conjugated linoleic acid induce insulin resistance through a mechanism involving activation of protein kinase cepsilon in liver cells. Cellular Signaling. (2019) 53: 281-293;
doi: 10.1016/j.cellsig.2018.10.013.

Acuña-Hernández DG, Arreola-Mendoza L, Santacruz-Márquez R, García-Zepeda SP, Parra-Forero LY, Olivares-Reyes JA, Hernández-Ochoa I. Bisphenol A alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex. Toxicol Appl Pharmacol. (2018) 344, 13-22;
doi: 10.1016/j.taap.2018.02.011.

Márquez-Gómez, R., Robins, M. T., Gutiérrez-Rodelo, C., Arias, J. M., Olivares-Reyes, J. A., van Rijn, R. M., and Arias-Montano, J. A. Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum. Pharmacological Research. (2018) 129: 515-525;
doi: 10.1016/j.phrs.2017.11.036.

Vázquez-Jiménez, J. G., Roura-Guiberna, A., Jiménez-Mena, L. R., y Olivares-Reyes, J. A. El Papel de los Ácidos Grasos Libres en la Resistencia a la Insulina. Gaceta Médica de México, (2017) 153(7):852-863.

Osorio-Yañez, C., Chin-Chan, M., Sánchez-Peña, L. C., Atzatzi-Aguilar, O. G., Olivares-Reyes, J. A., Segovia, J., Del Razo, L. M. The ADMA/DDAH/NO pathway in human vein endothelial cells exposed to arsenite. Toxicology in Vitro, (2017) 42:281-286;
doi: 10.1016/j.tiv.2017.05.008.

Gutiérez-Rodelo, C., Roura-Guiberna, A., y Olivares-Reyes, J. A. Mecanismos Moleculares de la Resistencia a la Insulina: Una Actualización. Gaceta Médica de México, (2017) 153(2):214-228.

Vazquez-Jimenez, J. G., Chavez-Reyes J., Romero-Garcia T., Zarain-Herzberg A., Valdes-Flores J., Galindo-Rosales J. M., Rueda A., Guerrero-Hernandez A., and Olivares-Reyes J. A. Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. Cell Signal, (2016) 28(1):53-9;
doi: 10.1016/j.cellsig.2015.10.001.

Guerrero-Hernández, A., Leon-Aparicio, D., Chavez-Reyes, J., Olivares-Reyes, J. A., De Jesus, S. Endoplasmic reticulum stress in insulin resistance and diabetes. Cell Calcium, (2014) 56(5):311-22;
doi: 10.1016/j.ceca.2014.08.006.

Hauger, R. L., Olivares-Reyes, J. A., Braun, S., Hernandez-Aranda, J., Hudson, C. C., Gutknecht, E., Dautzenberg, F. M., Oakley, R. H. Desensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment. Regul. Pept., (2013) 186:62-76;
doi: 10.1016/j.regpep.2013.06.009.

Martel-Gallegos, G., Casas-Pruneda, G., Ortega-Ortega, F., Sánchez-Armass, S., Olivares-Reyes, J. A., Diebold, B., Pérez-Cornejo, P., Arreola, J. Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2. Biochim Biophys Acta. (2013) 1830(10):4650-9;
doi: 10.1016/j.bbagen.2013.05.023.

Hauger, R. L., Olivares-Reyes, J. A., Dautzenberg, F. M., Lohr, J. B., Braun, S., Oakley, R. H. Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy. Neuropharmacology. (2012) 62(2):705-14;
doi: 10.1016/j.neuropharm.2011.11.007.

Pérez-Díaz, I., Guzmán, C., Olivares-Reyes, J. A., Ramírez, T., Gutierréz-Reyes, G., Hiriart, M., Robles-Díaz, G. Evidence of an intracellular angiotensin-generating system and non-AT1, non-AT2 binding site in a human pancreatic cell line. Pancreas. (2011) 40(5):701-7;
doi: 10.1097/MPA.0b013e318215a891.

Arellano-Plancarte, A., Hernandez-Aranda, J., Catt, K. J., Olivares-Reyes, J. A.. Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells. Biochem Pharmacol. (2010) 79(5):733-45;
doi: 10.1016/j.bcp.2009.10.014.

Hauger, R. L., Risbrough, V., Oakley, R. H., Olivares-Reyes, J. A., Dautzenberg, F. M. Role of CRF receptor signaling in stress vulnerability, anxiety and depression. Annals of the New York Academy of Science. (2009) 1179:120-43;
doi: 10.1111/j.1749-6632.2009.05011.x.

Olivares-Reyes, J. A., Arellano-Plancarte A. and Castillo Hernández, J. R. Angiotensin II and the development of insulin resistance: implications for diabetes. Mol Cel Endocrinol, (2009) 302(2):128-39;
doi: 10.1016/j.mce.2008.12.011.

Olivares-Reyes, J.A. y Plancarte-Arellano A. Bases Moleculares de las Acciones de la Insulina. Revista de Educación Bioquímica, (2008) 27(2):9-18.

Oakley, R. H., Olivares-Reyes, J.A., Hudson, C. C., Flores-Vega, F., Dautzenberg, F. M. and Hauger, R. L. Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am J Physiol Regul Integr Comp Physiol, (2007) 293(1):R209-22.

Pérez-Díaz, I., Hiriart, M., Olivares-Reyes, J.A., Robles-Díaz, G. Receptores para la angiotensina II diferentes a los clásicos receptores AT1 y AT2: Características y su papel en el funcionamiento celular. Revista de Educación Bioquímica, (2006) 25(2):55-60.

Olivares-Reyes, J.A., Shah B.H., Hernández-Aranda, J., García-Caballero, A., Parvaiz Farshori, M., García-Sainz, J.A. and Catt, K.J. Agonist-Induced interactions between angiotensin AT1 and epidermal growth factor receptors. Mol. Pharmacol. (2005) 68(2):356-64.

Shah, B.H., Olivares-Reyes, J.A., Catt, K.J. The protein kinase C inhibitor, Go6976 [12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a) pyrrolo(3,4-c)-carbazole] potentiates agonist-induced mitogen-activated protein kinase activation through tyrosine phosphorylation of the epidermal growth factor receptor. Mol. Pharmacol. (2005) 67(1):187-194.

Dautzenberg, F.M., Gutknecht, E., van der Linden, I., Olivares-Reyes, J.A., Dürrenberger, F. and Hauger, R.L. Cell type specific calcium signaling by corticotropin-releasing factor type 1 (CRF1) and 2a (CRF2(a)) receptors: Gq coupling in human embryonic kidney 293 but not SK-N-MC neuroblastoma cells. Biochem Pharmacol. (2004) 68(9):1833-44.

Shah, B.H., Yesilkaya, A., Olivares-Reyes, J.A., Chen, H-D., Hunyady, L., and Catt, K.J. Differential pathways of angiotensin II-induced ERK1/2 phosphorylation in specific cell types: role of heparin-binding epidermal growth factor. Mol Endocrinol. (2004), 18(8):2035-48.

Hauger, R.L., Olivares-Reyes, J.A., Braun, S., Catt, K.J., and Dautzenberg, F.M. Mediation of CRF1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation. J Pharmacol Exp Therap. (2003), 306(2):794-803.

Hunyady L., Baukal A.J., Gaborik Z., Olivares-Reyes J.A., Bor M., Szaszak M., Lodge R., Catt K.J., Balla T. Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor. J. Cell. Biol. (2002), 157(7):1211-1222.

Shah, B.H., Olivares-Reyes, J.A., Yesilkaya, A., & Catt, K.J. Independence of angiotensin II-induced MAP kinase activation from AT1-receptor internalization inclone 9 hepatocytes. Mol. Endo. (2002), 16(3):610-620.

Olivares-Reyes, J.A., Smith, R.D., Hunyady, L., Shah, B.H., & Catt, K.J. Agonist-induced signaling, desensitization and internalization of a phosphorylation-deficient AT1a angiotensin receptors. J. Biol. Chem. (2001) 276(41):37761-37768.

Garcia-Caballero, A., Olivares-Reyes, J.A., Catt, K.J. & Garcia-Sainz, J.A. Angiotensin AT1 receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase C and phosphoinositide 3-kinase. Molecular Pharmacology. (2001), 59(3):576-585.

Catt, K. J., Olivares-Reyes, A.J., Zhang, M., Smith, R.D. & Hunyady L. Activation and phosphorylation of angiotensin AT1 and AT2 receptors. Endocrinology Research. (2000), 26(4):559-560.

Olivares-Reyes, J.A., Jayaved, S., Hunyady, L., Catt, K.J. & Smith, R.D. Homologous and heterologous phosphorylation of the AT2 angiotensin receptor. Molecular Pharmacology. (2000), 58(5):1156-1161.