Dr. Ricardo Mondragón Flores

Professor (Cinvestav 3-C)
Member of the National System of Investigators (SNI 3)


Research lines:

Mechanisms of invasion of Toxoplasma. Proteomic, cellular and molecular characterization of components from T. gondii cytoskeleton. Participation of proteases from T. gondii in invasion and tissue dissemination. Modification of host cell properties (cytoskeleton organization, intercellular junctions, cell cycle, etc) by invasion and intracellular proliferation of T. gondii. Induction of cystogenesis in vitro and characterization of biochemical and cellular processes involved. Search and design of molecules with parasiticidal effects against Toxoplasma in vitro and in vivo models of toxoplasmosis. Immunochemistry characterization of Toxoplasma antigens during chronic and acute toxoplasmosis. Search of immunogenic peptides with protective properties in a murine model of toxoplasmosis.


Phone:  (52) (55) 5747-3949
E-mail: rmflores@yupisnoopycinvestav.mx

 

 

Some Representative Publications

Alma Reyna Escalona-Montaño, Mariana Zuñiga-Fabián, Nallely Cabrera , Ricardo Mondragón-Flores, Jenny Nancy Gómez-Sandoval, Araceli Rojas-Berbabe, Augusto González-Canto, Laila Gutiérrez-Kobeh, Ruy Pérez-Montfort, Ingerborg Becker and María Magdalena Aguirre-García. Protein serine/threonine phosphatase type 2C (PP2C) of Leishmania mexicana. Frontiers in Cellular and Infection Microbiology 11: 1-11: 2021.
doi: 10.3389/fcimb.2021.641356

Carlos J. Ramírez-Flores and Ricardo Mondragón-Flores. Elucidating the Role of Extracellular Vesicles Released by Toxoplasma gondii: A Review. Journal of Data Mining in Genomics 12(1000233): 1-12: 2021

Rosalba Cruz-Mirón, Carlos J. Ramírez-Flores, Noé Lagunas-Cortés, Mónica Mondragón-Castelán, Emmanuel Ríos-Castro, Sirenia González-Pozos, M. Magdalena Aguirre-García and Ricardo Mondragón-Flores. Proteomic characterization of the pellicle of Toxoplasma gondii. Journal of Proteomics 237: 1-15: 2021
doi: 10.1016/j.jprot.2021.104146

Sandra Chánez-Paredes, Armando Montoya-García, Karla F. Castro-Ochoa, Julio García-Cordero, Leticia Cedillo-Barrón, Mineko Shibayama, Porfirio Nava , Sven Flemming, Nicolas Schlegel, Alexis M. Gautreau, Hilda Vargas-Robles, Ricardo Mondragón-Flores and Michael Schnoor. The Arp2/3 Inhibitory Protein Arpin Is Required for Intestinal Epithelial Barrier Integrity. Frontiers in Cell and Developmental Biology 9(625719): 1-19: 2021.
doi: 10.3389/fcell.2021.625719

Moisés León-Juárez, Macario Martínez-Castillo, Gaurav Shrivastava, Julio García-Cordero, Nicolás Villegas-Sepulveda, Mónica Mondragón-Castelán, Ricardo Mondragón-Flores and Leticia Cedillo Barrón. Recombinant Dengue virus protein NS2B alters membrane permeability in different membrane models. Virology Journal. (2016), 13:1: 1-11;
doi: 10.1186/s12985-015-0456-4

Jorge Reyes-Esparza, Alberto Martínez-Mena, Ivonne Gutiérrez-Sancha, Patricia Rodríguez-Fragoso, Gerardo González de la Cruz, R. Mondragón, Lourdes Rodríguez-Fragoso. Synthesis, characterization and biocompatibility of cadmium sulfide nanoparticles capped with dextrin for in vivo and in vitro imaging application. J. Nanobiotechnol. (2015), 13:83: 2-14;
doi: 10.1186/s12951-015-0145-x

Toxoplasma gondii, un patógeno asesino re-emergente. Saé Muñiz Hernández, Ricardo Mondragón. Revista de Investigación Bioquímica. 2009. 28(2):52-58.

Federico Martínez-Gómez, Luis Francisco García-González, Ricardo Mondragón-Flores, Carlos Ramón Bautista-Garfias. Protection against Toxoplasma gondii brain cyst formation in mice immunized with Toxoplasma gondii cytoskeleton proteins and Lactobacillus casei as adjuvant. Veterinary Parasitology. 2009, 160(3-4):311-315.

M González del Carmen, M Mondragón, S González and R Mondragón. Induction and regulation of conoid extrusion in Toxoplasma gondii. Cellular Microbiology. 2009, 11(6): 967-982.

Edgar Abarca-Rojano, Saé Muñiz Hernández, María Maximina Bertha Moreno-Altamirano, Ricardo Mondragón-Flores, Fernando Enriquez-Rincón and F. Javier Sánchez-García. Re-organization of mitocondria in the human NK cell immune synase indued by interaction with tumor cels: a posible tole of NKG2D receptor. Immunology letters. 2009, 122: 18-25.

Victoria Ramos-Kichik, Ricardo Mondragón-Flores, Mónica Mondragón-Castelán, Sirenia González-Pozos, Sae Muñiz-Hernández, Oscar Rojas-Espinosa, Rommel Chacon-Salinas, Sergio Estrada-Parra and Iris Estrada-García. Neutrophil Extracellular Traps are induced by Mycobacterium tuberculosis. Tuberculosis. 2009, Jan; 89(1): 29-37.

M. Guadalupe Morales-García, Jean Jacques-Fournié, M. Maximina Bertha Moreno-Altamirano, Gabriela Rodríguez-Luna, Ricardo Mondragón-Flores, F. Javier Sánchez-García. A flow-cytometry method for analyzing the composition of membrane rafts (p NA). Cytometry. 2008, 73(10): 918-925.

Rafael Rodríguez-Muñoz, Marcela Villareal-Silva, Ricardo González-Ramírez, Francisco García-Sierra, Ricardo Mondragón, Mónica Mondragón, Joel Cerna and Bulmaro Cisneros. Association of dystrophin Dp71d to the nuclear matrix is modulated during PC12 cell neuronal differentiation. Biochemical and Biophysical Research Communications. 2008, 375: 303-307.

Cyrille Botté, Nadia Saidani, Ricardo Mondragón, Mónica Mondragón, Giorgis Isaac, Ernst Mui, Rima McLeod, Jean-Francois Dubremetz, Henri Vial, Ruth Welti, Marie-France Cesbron-Delaw, Corinne Mercier, Eric Marechal. Subcellular localization and dynamics of a digalactolipid-like lipid in Toxoplasma gondii. Journal of Lipid Research. 2008, 49: 746-762.

Laetitia Travier, Ricardo Mondragón-Flores, Jean-Francois Dubremetz, Karine Musset, Mónica Mondragón, Sirenia González, Marie-France Cesbron-Delaw, C. Mercier. Functional domains of the Toxoplasma GRA2 protein in the formation of the Membranous Nanotubular Network of the parasitophorous vacuole. International Journal of Parasitology. 2008, 38: 757-773.

D. Cerecedo, R. Mondragón, A. Candelario, F. García Sierra, D. Mornet, A. Rendón, D. Martínez. Utrophins compensate for Dp71 absence in mdx3cv in adherid platelets. Blood Coagulation and Fibrinolysys. 2008, 19: 39-47.

Doris Cerecedo, Ricardo Mondragón, Bulmaro Cisneros, Francisco Martínez, Dalila Martínez Rojas and Alvaro Rendón. Role of dystrophins and utrophins in platelet adhesion process. British Journal of Haematology. 2006, 134: 83-91.

Doris Cerecedo, Sirenia González, Mónica Mondragón, Elba Reyes, Ricardo Mondragón. In-vitro model for the ultrastructural study of the formation of thrombi in human platelets. Blood Coagulation and Fibrinolysis. 2006, 17(2): 161-164.

Cerecedo D., Martínez D., Chávez O., Martínez F., García F., Rendón A., Mornet D., Mondragón R. Platelet adhesion: Structural and functional diversity of short dystrophin and utrophins in the formation of dystrophin-associated protein complexes related to actin dynamics. Thrombosis and Haemostasis. 2005, 94:1203-1212.

A. Patrón, M. Mondragón, S. González, J. R. Ambrosio, A. L. Guerrero and R. Mondragón. Identification and purification of actin from the subpellicular network of Toxoplasma gondii tachysoites. International Journal of Parasitology. 2005, 35:883-894.

Ocampo J., Mondragón R., Roa-Espitia A. L., Salgado Z. O., Mujica A. Actin, myosin, cytokeratins and spectrin are components of the Guinea pig sperma nuclear matrix. Tissue & Cell. 2005, 37:293-308.

Quintana-Hau J.D., E. Cruz, López M.I., Sánchez V., Baiza L., González J.R., Mondragón-Flores R., Hernández A., Tornero R. Characterization of the novel ophtalmic drug carrier Sophisen in two of its derivatives: 3A Ofteno and Modusik-A Ofteno. Drug Development and Industrial Pharmacy. 2005, 31: 263-269.

Abarca-Reojano E., Rosas-Medina P., Zamudio-Cortez P., Mondragón-Flores R., Sánchez-García F. J. Mycobacterium tuberculosis virulence correlates with mitochondrial cytochrome c release in infected macrophages. Scand J Immunol. 2003 Oct, 58(4):419-27.

García-Pérez B. E., Mondragón-Flores R., Luna-Herrera J. Internalization of Mycobacterium tuberculosis by macropinocytosis in non-phagocytic cells. Microb. Pathog. 2003 Aug, 35(2):49-55.

D. Cerecedo, R. Stock, S. González, E. Reyes, R. Mondragón. Modification of actin, myosina and tubulin distribution during cytoplasmic granule movements associated with platelet adhesion. Haematologica. 87; 2002: 1165-1176.

A. Castillo, J. L. Reyes, E. Sánchez, R. Mondragón, I. Meza. 2,3-Butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers. Journal of Muscle Research and Cell Motility. 23(3): 2002: 223-234.

K. Sengupta, V. Hernández, A. Ríos, R. Mondragón and P. Talamas. Entamoeba hystolitica: monoclonal antibody against the b1 integrin-like molecule (140kDa) inhibits cell adhesion to extracellular matrix components. Experimental Parasitology. 98(2): 2001: 83-89.

C. García, T. A. Pérez, J. Luna, R. Mena, B. Osorio, V. Alemán, R. Mondragón, D. Mornet and J.M. Hernández. Biochemical and histochemical analysis of 71kDa dystrophin isoform (DP71f) in rat brain. Acta Histochemica. 103: 2001: 209-224.

Vega-López M., Arenas C. G., Bailey M., González P. S., Stokes C. R., Ortega P. G. and Mondragón F. R. Development on intraepithelial cells in the porcine small intestine. Developmental Immunology. 2001, 8(2): 147-158.

 

 

 

 

 

 

 


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DEPARTAMENTO DE BIOQUÍMICA

Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Alcaldía Gustavo A. Madero
C. P. 07360, Ciudad de México, Apartado Postal: 14-740, 07000


 

Contáctanos
Coordinación Académica
(+52) 55 57 47 38 00, Ext. 5216
Horario:  10:00h a 18:00h
coordinacion.bq@yupisnoopycinvestav.mx

Posgrados
Maestría
Doctorado

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