Dr. Agustín Guerrero Hernández

Professor (Cinvestav 3-D)
Member of the National System of Investigators (SNI 2)

Research lines:

Intracellular calcium regulation in smooth muscle cells. Ca2+ release via ryanodine and IP3 receptors. Role of SERCA pumps regulating sarcoplasmic reticulum Ca2+ release. Protein-protein interaction of SERCA pumps. Role of SERCA pumps in diabetes and insulin-resistance state. Role of insulin in agonist-induced Ca2+ release. Role of ion channels in apoptosis. Mechanism of cytochrome c release from mitochondria in apoptosis. Mathematical models of Ca2+ release by Ryanodine receptors or IP3Rs.

Phone:  (52) (55) 5747-3950
E-mail: aguerrero@yupisnoopycinvestav.mx



Some Representative Publications

Daniel Leon-Aparicio, Jesus Chavez-Reyes, Agustin Guerrero-Hernandez. Activation of endoplasmic reticulum calcium leak by 2-APB depends on the luminal calcium concentration. Cell Calcium. (2017) pii: S0143-4160(16)30136-1;
doi: 10.1016/j.ceca.2017.01.013.

Daniel Leon-Aparicio, Jonathan Pacheco, Jesus Chavez-Reyes, Jose M. Galindo, Jesus Valdes, Luis Vaca, Agustin Guerrero-Hernandez. ORAI3 channel is the 2-APB-induced endoplasmic reticulum calcium leak. Cell Calcium. (2017) pii: S0143-4160(16)30137-3;
doi: 10.1016/j.ceca.2017.01.012.

David R. de Alba-Aguayo, Natalia Pavón, Martha Mercado-Morales, Miyamin Miranda-Saturnino, Mavil López-Casamichana, Agustin Guerrero-Hernández, Angélica Rueda. Increased calcium leak associated with reduced calsequestrin expression in hyperthyroid cardiomyocytes. Cell Calcium. (2017) 62:29-40;
doi: 10.1016/j.ceca.2017.01.009.

Rivera-Ramírez N, Montejo-López W, López-Méndez MC, Guerrero-Hernández A, Molina-Hernández A, García-Hernández U, Arias-Montaño JA. Histamine H3 receptor activation stimulates calcium mobilization in a subpopulation of rat striatal neurons in primary culture, but not in synaptosomes. Neurochem Int. (2016) 101:38-47;
doi: 10.1016/j.neuint.2016.10.005.

Gustavo Vazquez-Jimenez J, Chavez-Reyes J, Romero-Garcia T, Zarain-Herzberg A, Valdes-Flores J, Manuel Galindo-Rosales J, Rueda A, Guerrero-Hernandez A, Alberto Olivares-Reyes J. Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. Cell Signal. (2016) 28(1):53-59;
doi: 10.1016/j.cellsig.2015.10.001.

Pérez-Rosas NC, Gómez-Víquez NL, Dagnino-Acosta A, Santillan M, Guerrero-Hernández A. Kinetics on Demand Is a Simple Mathematical Solution that Fits Recorded Caffeine-Induced Luminal SR Ca2+ Changes in Smooth Muscle Cells. PLoS One. (2015) 10(9):e0138195;
doi: 10.1371/journal.pone.0138195.

E. Benítez-Rangel, MC López-Méndez, L García and A Guerrero-Hernández. DIDS (4,4'-Diisothiocyanatostilbene-2,2'-disulfonate) directly inhibits caspase activity in HeLa cell lysates. Cell Death Discovery. (2015) 1:e15037;
doi: 10.1038/cddiscovery.2015.37.

Guerrero-Hernández A, Gallegos-Gomez ML, Sanchez-Vazquez VH, Lopez-Mendez MC. Acidic intracellular Ca2+ stores and caveolae in Ca2+ signaling and diabetes. Cell Calcium. (2014) 56(5):323-331;
doi: 10.1016/j.ceca.2014.08.005.

Guerrero-Hernández A, Leon-Aparicio D, Chavez-Reyes J, Olivares-Reyes JA, DeJesus S. Endoplasmic reticulum stress in insulin resistance and diabetes. Cell Calcium. (2014) 56(5):311-322;
doi: 10.1016/j.ceca.2014.08.006.

Guerrero-Hernández A, Verkhratsky A. Calcium signalling in diabetes. Cell Calcium. (2014) 56(5):297-301;
doi: 10.1016/j.ceca.2014.08.009.

Guerrero-Hernández A, Ávila G, Rueda A. Ryanodine receptors as leak channels. European Journal of Pharmacology. (2014) 739:26-38;
doi: 10.1016/j.ejphar.2013.11.016.

E Benítez-Rangel, L García, MC Namorado, JL Reyes and A Guerrero-Hernández. Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration. Cell Death and Disease. (2011) 2, e113;
doi: 10.1038/cddis.2010.93.

Agustin Guerrero-Hernández, Adan Dagnino-Acosta and Alexej Verkrahstky. An intelligent sarco-endoplasmic reticulum Ca2+ store: Release and leak channels have differential access to a concealed Ca2+ pool. Cell Calcium. (2010) 48(2-3):143-149;
doi: 10.1016/j.ceca.2010.08.001.

Leticia Gomez-Viquez, Guadalupe Guerrero-Serna, Fernando Arvizu, Ubaldo García and Guerrero-Hernández A Inhibition of SERCA pumps induces desynchronized RyR activation in overloaded internal Ca2+ stores in smooth muscle cells. American J. of Physiology. (2010) 298(5):C1038-C1046;
doi: 10.1152/ajpcell.00222.2009.

Dagnino-Acosta A, Guerrero-Hernández A. Variable luminal sarcoplasmic reticulum Ca2+ buffer capacity in smooth muscle cells. Cell Calcium. (2009) 46(3):188-196;
doi: 10.1016/j.ceca.2009.07.005.

Guerrero-Cazares Hugo, Alatorre-Carranza María del Pilar, Delgado-Rizo Vidal, Duena-Jimenez Judith Marcela, Mendoza-Magana María Luisa, Morales-Villagran Alberto, Ramirez-Herrera Mario A., Guerrero-Hernández Agustín, Segovia Jose, Duenas-Jimenez Sergio H. Dopamine release modifies intracellular calcium levels in tyrosine hydroxylase-trasfected C6 cells. Brain Research Bulletin. (2007) 74(1-3):113-118.

Agustín Guerrero-Hernández, Ubaldo Garcia, Leticia Gomez-Viquez, Guadalupe Guerrero-Serna, Moises Santillan. Modulation by SERCA pumps of Ca2+ release from internal stores in smooth muscle cells. J Muscle Res Cell Motil. (2004) 25(8):618-620.

Gómez-Viquez, L., Rueda, A., García, U., Guerrero-Hernández, A. Complex effects of ryanodine on the sarcoplasmic reticulum Ca2+ levels in smooth muscle cells. Cell Calcium. (2005) 38(2):121-30.

García-Rivas G.J., Guerrero-Hernández, A., Guerrero-Serna, G., Rodríguez-Zavala, J.S. and Zazueta, C. Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart. FEBS J. (2005) 272(13):3477-88.

Leticia Gómez-Viquez, Guadalupe Guerrero-Serna, Ubaldo García and Agustín Guerrero-Hernández. SERCA pump optimizes Ca2+ release by a mechanism independent of store filling in smooth muscle cells. Biophysical Journal. (2003) 85(1):370-380.

Beatriz Aguilar-Maldonado, Leticia Gómez-Viquez, Lucía García, Rosa M. Del Angel, José Antonio Arias-Montaño and Agustín Guerrero-Hernández. Histamine potentiates IP3-mediated Ca2+ release via thapsigargin-sensitive Ca2+ pumps. Cellular Signalling. (2003) 15(7):689-697.

Agustín Guerrero-Hernández, Leticia Gómez-Viquez, Guadalupe Guerrero-Serna and Angélica Rueda. Ryanodine receptors in smooth muscle. Frontiers in Bioscience. (2002) 7:d1676-1688.

Angélica Rueda, Lucía García, Luis Enrique Soria-Jasso, José Antonio Arias-Montaño and Agustín Guerrero-Hernández. The initial inositol (1,4,5) trisphosphate response induced by histamine is strongly amplified by Ca2+ release from internal stores in smooth muscle. Cell Calcium. (2002) 31(4):161-173.

Angélica Rueda, Lucía García, and Agustín Guerrero-Hernández. Luminal Ca2+ and the activity of sarcoplasmic reticulum Ca2+ pumps modulate histamine-induced all-or-none Ca2+ release in smooth muscle cells. Cellular Signalling. (2002) 14(6):517-527.

Agustín Guerrero and Juan Manuel Arias. Capítulo 68 "Apoptosis" en Cell Physiology Sourcebook, A Molecular Approach, 3ra. ed. editado por Nicholas Sperelakis, Academic Press. (2001) pp 1171-1184.

Michael T. Kirber, Agustín Guerrero-Hernández, Douglas S. Bowman, Kevin Fogarty, Richard A. Tuft, Joshua J. Singer and Frederic S. Fay. Multiple pathways responsible for the stretch-induced increase in calcium concentration in toad stomach smooth muscle cells. Journal of Physiology. (2000) 524(Pt 1):3-17.

Gutierrez, A.A., Arias, J.M., García, L., Mas-Oliva, J. and Guerrero, A. Activation of Ca2+ permeable cation channel by two different inducers of apoptosis in a human prostatic cancer cell line. J. Physiol. (1999) 517(Pt 1):95-107.

Agustín Guerrero and Juan Manuel Arias. Capítulo 67 "Apoptosis" en Cell Physiology Source Book, 2da. ed. editado por Nicholas Sperelakis, Academic Press (1998) pp 1031-1043.

Guerrero, A., García, L., Zapata, O., Rodríguez, E. and Darszon, A. Acrosome reaction inactivation in sea urchin sperm. Biochim. Biophys. Acta. (1998) 1401(3):329-38.

Muñoz, A., García, L. and Guerrero-Hernández, A. In situ characterization of the Ca2+ sensitivity of large conductance Ca2+-activated K+ channels: Implications for their use as near-membrane Ca2+ indicators in smooth muscle cells. Biophys. J. (1998) 75(4):1774-82.

Agustín Guerrero, Joshua J. Singer and Fredric S. Fay. Simultaneous measurement of Ca2+ release and influx into smooth muscle cells in response to caffeine. A novel approach for calculating the fraction of current carried by calcium. Journal of General Physiology. (1994) 104(2):395-422.

Agustín Guerrero, Fredric S. Fay and Joshua J. Singer. Caffeine activates a Ca2+ permeable, nonselective cation channel in smooth muscle cells. Journal of General Physiology. (1994) 104(2):375-394.

Le Xu, Anthony Lai, Anita Cohn, Elaine Etter, Agustín Guerrero, Fredric S. Fay and Gerhard Meissner. Evidence for a Ca2+-gated ryanodine-sensitive Ca2+ release channel in visceral smooth muscle. Proceedings of the National Academy of Sciences, USA. (1994) 91(8):3294-3298.